Modeling cell population dynamics

Modeling and prediction of cell population dynamics

Oscillatory yeast cell dynamics are observed in glucose-limited growth environments. Under such conditions, both glucose and the excreted product ethanol can serve as substrates for cell growth. The cell dynamics is described by a PDE (partial differential equation) system containing one PDE for the cell population and 8 ODEs for 8 substrates variations (extracellular glucose, extracellular eth...

Modeling Population Dynamics

Modeling Population Dynamics

Modeling bacterial population growth from stochastic single-cell dynamics.

A few bacterial cells may be sufficient to produce a food-borne illness outbreak, provided that they are capable of adapting and proliferating on a food matrix. This is why any quantitative health risk assessment policy must incorporate methods to accurately predict the growth of bacterial populations from a small number of pathogens. In this aim, mathematical models have become a powerful tool...

Cell population balance and hybrid modeling of population dynamics for a single gene with feedback

Latest research on biological systems is steadily shifting from isolated single cells to entire cell populations. The latter are inherently heterogeneous, and their modeling requires approaches that explicitly account for this property. A comprehensive such approach is the cell population balance (CPB), which, however, is computationally expensive and becomes intractable for multivariable model...